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Susumu Higuchi Selected Research

Acetaldehyde

1/2019Telomere shortening in alcohol dependence: Roles of alcohol and acetaldehyde.
8/2017Review: Use of Asian samples in genetic research of alcohol use disorders: Genetic variation of alcohol metabolizing enzymes and the effects of acetaldehyde.
5/2016Alcohol Dehydrogenase-1B (rs1229984) and Aldehyde Dehydrogenase-2 (rs671) Genotypes and Alcoholic Ketosis Are Associated with the Serum Uric Acid Level in Japanese Alcoholic Men.
3/2016Blood Leukocyte Counts and Genetic Polymorphisms of Alcohol Dehydrogenase-1B and Aldehyde Dehydrogenase-2 in Japanese Alcoholic Men.
5/2009Association between personality traits and ALDH2 polymorphism in Japanese male alcoholics.
3/2007p53 Protein accumulation, cancer multiplicity, and aldehyde dehydrogenase-2 genotype in Japanese alcoholic men with early esophageal squamous cell carcinoma.
9/2006Melanosis and squamous cell neoplasms of the upper aerodigestive tract in Japanese alcoholic men.
7/2005Esophageal melanosis, an endoscopic finding associated with squamous cell neoplasms of the upper aerodigestive tract, and inactive aldehyde dehydrogenase-2 in alcoholic Japanese men.
6/2004Association of aldehyde dehydrogenase-2 polymorphism with alcoholic polyneuropathy in humans.
1/2004Acetaldehyde accumulation suppresses Kupffer cell release of TNF-Alpha and modifies acute hepatic inflammation in rats.
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Susumu Higuchi Research Topics

Disease

33Alcoholism (Alcohol Abuse)
11/2021 - 03/2003
7Neoplasms (Cancer)
01/2019 - 11/2003
7Alzheimer Disease (Alzheimer's Disease)
05/2009 - 11/2002
6Dementia (Dementias)
04/2014 - 01/2005
4Liver Cirrhosis (Hepatic Cirrhosis)
03/2016 - 11/2003
3Flushing
01/2020 - 11/2003
3Substance-Related Disorders (Drug Abuse)
10/2011 - 11/2004
3Squamous Cell Carcinoma (Epidermoid Carcinoma)
03/2007 - 11/2003
2Tobacco Use Disorder (Nicotine Dependence)
06/2020 - 10/2017
2Ketosis
05/2016 - 11/2014
2Macrocytic Anemia
03/2016 - 05/2014
2Fibrosis (Cirrhosis)
01/2015 - 08/2013
2Malnutrition (Nutritional Deficiencies)
05/2014 - 04/2014
2Liver Diseases (Liver Disease)
04/2014 - 08/2013
2Stomach Neoplasms (Stomach Cancer)
03/2013 - 02/2007
2Alcohol Withdrawal Delirium (Delirium Tremens)
06/2008 - 08/2003
2Esophageal Squamous Cell Carcinoma
03/2007 - 11/2003
2Melanosis (Freckles)
09/2006 - 07/2005
2Pancreatitis
05/2005 - 03/2003
2Feeding and Eating Disorders (Eating Disorder)
07/2004 - 05/2004
1Vomiting
08/2020
1Sleepiness
08/2020
1Nausea
08/2020
1Nasopharyngitis
08/2020
1Dizziness (Lightheadedness)
08/2020
1Sleep Initiation and Maintenance Disorders (Insomnia)
01/2020
1Thrombocytopenia (Thrombopenia)
01/2017
1Mental Disorders (Mental Disorder)
09/2015
1Delirium
09/2015
1Mood Disorders (Mood Disorder)
01/2015
1Hypoglycemia (Reactive Hypoglycemia)
11/2014
1Traumatic Brain Injuries (Traumatic Brain Injury)
04/2014
1Cerebrovascular Disorders (Cerebrovascular Occlusion)
04/2014
1Atrophy
01/2014
1Sleep Deprivation
12/2013
1Calcific Pancreatitis
08/2013
1Diabetes Mellitus
08/2013
1Hypertension (High Blood Pressure)
08/2013
1Body Weight (Weight, Body)
07/2013
1Peptic Ulcer (Peptic Ulcers)
03/2013
1Metabolic Bone Diseases (Osteopenia)
05/2010
1Wernicke Encephalopathy (Wernicke's Encephalopathy)
06/2008
1Korsakoff Syndrome (Wernicke-Korsakoff Syndrome)
06/2008
1Carcinoma (Carcinomatosis)
02/2007
1Atrophic Gastritis
02/2007

Drug/Important Bio-Agent (IBA)

16AldehydesIBA
01/2020 - 11/2003
11AcetaldehydeIBA
01/2019 - 11/2003
7Ethanol (Ethyl Alcohol)IBA
01/2019 - 03/2003
6EnzymesIBA
01/2018 - 08/2003
3Aldehyde DehydrogenaseIBA
01/2019 - 03/2003
3Apolipoproteins E (ApoE)IBA
05/2009 - 07/2006
3IodineIBA
11/2006 - 11/2003
3Brain-Derived Neurotrophic Factor (BDNF)IBA
11/2004 - 08/2003
2Silver Sulfadiazine (SSD)FDA LinkGeneric
01/2020 - 12/2013
2Neurotransmitter Agents (Neurotransmitter)IBA
11/2019 - 01/2015
2EndocannabinoidsIBA
01/2018 - 08/2007
2Folic Acid (Vitamin M)FDA LinkGeneric
05/2014 - 11/2003
2Disulfiram (Antabuse)FDA Link
02/2014 - 01/2004
2HomocysteineIBA
10/2011 - 01/2005
2ApolipoproteinsIBA
05/2009 - 07/2006
2Biomarkers (Surrogate Marker)IBA
02/2005 - 11/2002
2Cholecystokinin A ReceptorIBA
05/2004 - 01/2004
1TransferasesIBA
11/2021
1nalmefene (Revex)FDA Link
08/2020
1NicotineFDA Link
06/2020
13,4-dihydroxyphenylacetaldehydeIBA
11/2019
1Alcohol Dehydrogenase (Alcohol Dehydrogenase (NAD+))IBA
01/2019
1Lipoprotein Lipase (Diacylglycerol Lipase)IBA
01/2018
1Varenicline (Chantix)FDA Link
10/2017
1Complement System Proteins (Complement)IBA
11/2016
1Uric Acid (Urate)IBA
05/2016
1C-Reactive ProteinIBA
03/2016
1BenzodiazepinesIBA
09/2015
1Methylphenidate (Ritalin)FDA LinkGeneric
09/2015
1Antidepressive Agents (Antidepressants)IBA
09/2015
1Antipsychotic Agents (Antipsychotics)IBA
09/2015
1Acamprosate (Campral)FDA Link
02/2015
1LipidsIBA
01/2015
1BilirubinIBA
11/2014
1CarbohydratesIBA
11/2014
1Hemoglobins (Hemoglobin)IBA
05/2014
1ORALIT (ORS)IBA
05/2014
1Pemetrexed (MTA)FDA Link
01/2014
1Collagen Type IV (Type IV Collagen)IBA
08/2013
1Methamphetamine (Desoxyn)FDA LinkGeneric
10/2011
1Pharmaceutical PreparationsIBA
10/2011
1GABA Receptors (GABA Receptor)IBA
04/2011
1Biological ProductsIBA
04/2011
1GABA-A Receptors (GABA(A) Receptor)IBA
03/2011
1Aminobutyrates (Aminobutyric Acid)IBA
03/2011
1tau Proteins (tau Protein)IBA
06/2008
1Genetic Markers (Genetic Marker)IBA
08/2007
1Monoacylglycerol LipasesIBA
08/2007
1fatty-acid amide hydrolase (fatty acid amide hydrolase)IBA
08/2007
1Proteins (Proteins, Gene)FDA Link
03/2007

Therapy/Procedure

6Therapeutics
09/2015 - 01/2004
2Gastrectomy
03/2013 - 03/2003
1Length of Stay
01/2017
1Aftercare (After-Treatment)
02/2013
1Activities of Daily Living (ADL)
05/2010